Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Deep brain stimulation for psychiatric disorders.

Brian Harris Kopell1, Benjamin Greenberg, Ali R Rezai

  • 1Center for Neurological Restoration, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society
|April 21, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of Pediatric Demyelinating Diseases using Axonal and Myelin-Sensitive MRI.

AJNR. American journal of neuroradiology·2026
Same author

Focused ultrasound thalamotomy for essential tremor in octogenarians.

Journal of neurosurgery·2026
Same author

Memory Consolidation and ARIA in Individuals Receiving Anti-amyloid Monoclonal Antibodies.

The journal of prevention of Alzheimer's disease·2026
Same author

From complexity to commercial readiness: industry insights on bridging gaps in human-robot interaction and social robot navigation.

Frontiers in robotics and AI·2026
Same author

Dementia Care Research and Psychosocial Factors.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Acoustic emissions dose and spatial control of blood-brain barrier opening with focused ultrasound.

Device·2025
Same journal

Surface EEG to Identify Cognitive Motor Dissociation After Acute Brain Injury.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
Same journal

The Physics and Physiology of Electrical Stimulation of the Brain.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
Same journal

Neurophysiology in Postanoxic Encephalopathy: Pathophysiology, Prognosis, and Treatment.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
Same journal

A Review on the Functional Connectivity of the Human Opercular Cortex.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
Same journal

Surgical Aspects of Opercular Epilepsies.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
Same journal

Cost-Effectiveness of EEG Monitoring in Hypoxic-Ischemic Brain Injury After Cardiac Arrest.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
See all related articles

Deep brain stimulation (DBS) is a reversible neurosurgical technique offering adjustable treatment for movement disorders and refractory psychiatric conditions. Initial studies show promise for DBS in treating obsessive-compulsive disorder (OCD).

Area of Science:

  • Neurosurgery
  • Psychiatry
  • Neuroscience

Background:

  • Deep brain stimulation (DBS) has transformed movement disorder treatment.
  • DBS is being explored for refractory psychiatric conditions due to its advantages over lesioning.
  • Advantages include reversibility, adjustable stimulation, and suitability for double-blind studies.

Purpose of the Study:

  • To explore the potential of DBS in treating psychiatric disorders.
  • To identify appropriate surgical targets for psychiatric DBS.
  • To review the role of cortico-striato-thalamocortical (CSTC) loops in psychiatric pathophysiology.

Main Methods:

  • Review of functional imaging studies supporting the CSTC loop model.
  • Analysis of psychiatric and cognitive effects from movement disorder DBS.

Related Experiment Videos

  • Examination of published studies on DBS for obsessive-compulsive disorder (OCD).

    • Main Results:

    • CSTC loops are strongly implicated in the pathophysiology of psychiatric symptoms.
    • Functional imaging corroborates the CSTC loop model.
    • DBS can modulate neural systems involved in psychiatric phenomena, with initial OCD studies showing safety.

    Conclusions:

    • DBS is a promising, reversible, and adjustable neuromodulation technique for psychiatric disorders.
    • Targeting CSTC loops is a key strategy for psychiatric DBS.
    • While efficacy data for OCD are still emerging, initial results are encouraging.