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A case of multiple keratoacanthoma centrifugum marginatum
Cristina Mangas1, Isabel Bielsa, Miquel Ribera
1Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. cferran@ns.hugtip.scs.es
Summary
Multiple keratoacanthoma centrifugum marginatum, a rare skin tumor, was effectively treated with methotrexate and prednisone. This case highlights challenges in classifying and managing these exceptional keratoacanthoma variants.
Area of Science:
- Dermatology
- Oncology
Background:
- Keratoacanthoma centrifugum marginatum is a rare keratoacanthoma variant.
- Multiple lesions are exceptionally rare, typically presenting as solitary tumors.
Observation:
- A 21-year-old male presented with multiple erythematous papules and plaques on his legs.
- Histological examination confirmed keratoacanthoma centrifugum marginatum with peripheral growth.
- Initial treatment with oral isotretinoin was ineffective.
Findings:
- Combination therapy with methotrexate and oral prednisone achieved complete regression of all lesions.
- This treatment approach proved effective for multiple keratoacanthoma centrifugum marginatum.
Implications:
- The case challenges current classifications of keratoacanthoma variants.
- Effective management strategies for complex or multiple keratoacanthoma centrifugum marginatum cases are crucial.