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Related Experiment Videos

Implementation of HaemScreen, a workplace-based genetic screening program for hemochromatosis.

A E Nisselle1, M B Delatycki, V Collins

  • 1Genetic Health Services Victoria, Murdoch Childrens Research institute, University of Melbourne Department of Paediatrics, Bruce Lefroy Center for Genetic Health Research, Victoria, Australia.

Clinical Genetics
|April 22, 2004
PubMed
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Community genetic screening for hereditary hemochromatosis (HH) is acceptable in the workplace. The HaemScreen pilot demonstrated high participation and acceptance of C282Y HFE gene screening, with education improving understanding.

Area of Science:

  • Genetics
  • Public Health
  • Preventive Medicine

Background:

  • Hereditary hemochromatosis (HH) is a common, preventable iron overload disorder.
  • Over 90% of HH cases are linked to C282Y homozygosity in the HFE gene.
  • Debate exists regarding community genetic screening for HH due to penetrance, economic, and acceptance concerns.

Purpose of the Study:

  • To pilot C282Y screening in a workplace setting.
  • To assess understanding of genetic information and screening acceptability for HH.
  • To evaluate the effectiveness of group education methods.

Main Methods:

  • The HaemScreen program utilized oral or video group education.
  • C282Y status was determined via polymerase chain reaction (PCR) and melt-curve analysis.

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  • DNA was collected using cheek-brush sampling.

    • Main Results:

    • 5.8% of eligible participants attended information and screening sessions.
    • 97.7% of attendees chose to be tested, identifying 22 C282Y homozygotes (1:253) and 638 heterozygotes (1:8.7).
    • Participation determinants were analyzed using the Health Belief Model.

    Conclusions:

    • Widespread genetic screening for HH is readily accepted in a workplace setting.
    • A one-to-many education program is effective for HH screening.
    • Participation levels vary; workplace-specific adaptations for advertising and logistics are recommended.