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Microbarcode sorting device
Po Ki Yuen1, Mircea Despa, Cheng-Chung Jim Li
1Science and Technology, Corning Incorporated, Corning, New York 14831-0001, USA. yuenp@corning.com
Lab on a Chip
|April 22, 2004
Summary
A new microfluidic device sorts glass microbarcodes for efficient imaging after assays. This simple technology creates a monolayer of microbarcodes, preventing stacking and ensuring flat surfaces for analysis.
Area of Science:
- Microfluidics
- Biotechnology
- Assay Development
Background:
- Bead-based assays generate data using microbarcodes.
- Analyzing microbarcodes requires them to be flat and non-overlapping.
- Current methods for microbarcode preparation can be inefficient.
Purpose of the Study:
- To develop a novel microfluidic device for sorting microbarcodes.
- To enable efficient imaging or scanning of microbarcodes post-assay.
- To create a monolayer of microbarcodes for improved analysis.
Main Methods:
- A microfluidic device with a reservoir, sorting region, and microchannels was designed.
- Microbarcodes were dried and flowed through the device.
- The device trapped microbarcodes in a monolayer within the sorting region.
Main Results:
- The microfluidic device successfully sorted 20-micrometer thick glass microbarcodes.
- A monolayer of flat, non-stacked microbarcodes was consistently produced.
- Minimal loss of microbarcodes was observed during the sorting process.
Conclusions:
- The developed microfluidic device offers a simple and effective solution for microbarcode sorting.
- This technology facilitates convenient imaging and scanning for bead-based assays.
- The device's adaptability to different bead shapes and high-throughput formats shows broad applicability.