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Elemental fluorine. Part 13. Gas-liquid thin film microreactors for selective direct fluorination.

R D Chambers1, D Holling, R C Spink

  • 1Department of Chemistry, University of Durham, South Road, Durham, UKDH1 3LE. r.d.chambers@durham.ac.uk

Lab on a Chip
|April 22, 2004
PubMed
Summary

Continuous flow microreactors enable selective fluorination of diverse substrates and conversion of disulfides to sulfur pentafluorides. Scale-up was achieved using a replicated three-channel microreactor system.

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Area of Science:

  • Organic Chemistry
  • Chemical Engineering
  • Materials Science

Background:

  • Continuous flow chemistry offers advantages in safety and efficiency for chemical synthesis.
  • Microreactors provide enhanced mass and heat transfer, crucial for reactions involving gases and liquids.
  • Selective fluorination and sulfur fluoride synthesis are important transformations in organic chemistry.

Purpose of the Study:

  • To demonstrate the utility of continuous flow gas-liquid thin film microreactors for selective fluorination.
  • To showcase the conversion of aromatic disulfides to sulfur pentafluorides using microreactor technology.
  • To validate the scalability of the microreactor system through replication.

Main Methods:

  • Utilized continuous flow gas-liquid thin film microreactors.

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  • Employed a range of 1,3-dicarbonyl and aromatic substrates for fluorination.
  • Investigated the conversion of aromatic disulfides to sulfur pentafluorides.
  • Fabricated a three-channel microreactor device by replicating a single channel system for scale-up.

    • Main Results:

    • Achieved selective fluorination of various 1,3-dicarbonyl and aromatic compounds.
    • Successfully converted aromatic disulfides to the corresponding sulfur pentafluorides.
    • Demonstrated successful scale-up of the process using a replicated multi-channel microreactor.

    Conclusions:

    • Continuous flow microreactors are effective for selective fluorination and sulfur pentafluoride synthesis.
    • The microreactor system is amenable to scale-up, facilitating industrial application.
    • This technology offers a promising platform for efficient and selective synthesis of organofluorine compounds.