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Published on: December 18, 2016
Non-Alzheimer's disease dementias: anatomic, clinical, and molecular correlates
Craig E Hou1, Danielle Carlin, Bruce L Miller
1Department of Neurology, University of California at San Francisco, USA. craig.hou@memory.ucsf.edu
Objective:
To review the clinical and molecular features of non-Alzheimer's disease (non-AD) dementias, focusing on disorders associated with tau pathology (that is, frontotemporal lobar degeneration [FTLD], corticobasal ganglionic degeneration [CBD], and progressive supranuclear palsy [PSP]) or on disorders with synuclein pathology (that is, dementia with Lewy bodies [DLB] and multisystem atrophy [MSA]). We also discuss the pharmacologic treatment of these disorders.
Methods:
We report a selective review of the literature on FTLD, CBD, PSP, DLB, and MSA.
Results:
The non-AD dementias can present with a wide variety of cognitive and behavioural symptoms. Through common clinical features and shared molecular etiologies, neurodegenerative disorders previously thought to be distinct are now classified into tauopathies and synucleinopathies.
Conclusions:
The unique cognitive and behavioural manifestations of the non-AD dementias can be mistaken for psychiatric disorders. Improved detection of tauopathies and synucleinopathies and their differentiation from AD is possible.
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