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Solid-phase syntheses of furopyridine and furoquinoline systems
Pablo Cironi1, Judit Tulla-Puche, George Barany
1Biomedical Research Institute, Barcelona Scientific Park, Laboratory of Organic Chemistry, Faculty of Pharmacy, and Department of Organic Chemistry, University of Barcelona, 08028 Barcelona, Spain.
Organic Letters
|April 23, 2004
Abstract:
[reaction: see text] Syntheses of 2-substituted furo[3,2-b]pyridines and furo[3,2-h]quinolines have been achieved for the first time in the solid-phase mode. The central enabling steps involved concomitant deprotection/cyclization promoted by the mild base K(2)CO(3). Reactions were monitored "in situ" in real time by a variety of spectroscopic techniques, which allowed full and accurate control of progress in these syntheses.