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Related Experiment Videos

Mexiletine and persistent ophthalmic changes.

M S Leong1, F Isolani, R R Gaeta

  • 1Division of Pain Management, Department of Anesthesiology, Pain Management Services, Stanford University School of Medicine, Stanford, California, USA. msleong@stanford.edu

Pain Medicine (Malden, Mass.)
|April 23, 2004
PubMed
Summary
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Mexilitine, an anti-arrhythmic drug for neuropathic pain, may cause persistent eye changes. Patients with existing eye conditions should use mexilitine cautiously due to potential ophthalmic side effects.

Area of Science:

  • Pharmacology
  • Ophthalmology
  • Neurology

Background:

  • Mexilitine is an anti-arrhythmic medication commonly prescribed for neuropathic pain.
  • It is generally recognized for a favorable side-effect profile, with gastritis being the most frequent adverse event.
  • Ophthalmic side effects of mexilitine are not widely documented.

Purpose of the Study:

  • To report two cases suggesting mexilitine may induce persistent ophthalmic changes.
  • To highlight the potential risks of mexilitine in patients with pre-existing ocular conditions.

Main Methods:

  • Case report analysis of two patients treated with mexilitine for neuropathic pain.
  • Clinical examination and follow-up of ophthalmic parameters.

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Main Results:

  • Both patients experienced persistent ocular changes during mexilitine therapy.
  • These changes were noted despite the drug's generally low side-effect profile.

Conclusions:

  • Mexilitine may be associated with persistent ophthalmic alterations.
  • Caution is advised when prescribing mexilitine to chronic pain patients, particularly those with pre-existing ocular diseases.