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Mexiletine and persistent ophthalmic changes.

M S Leong¹, F Isolani, R R Gaeta

¹Division of Pain Management, Department of Anesthesiology, Pain Management Services, Stanford University School of Medicine, Stanford, California, USA. msleong@stanford.edu

Pain Medicine (Malden, Mass.)

|April 23, 2004

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Terms & Conditions of Use

Mexilitine, an anti-arrhythmic drug for neuropathic pain, may cause persistent eye changes. Patients with existing eye conditions should use mexilitine cautiously due to potential ophthalmic side effects.

Area of Science:

Pharmacology
Ophthalmology
Neurology

Background:

Mexilitine is an anti-arrhythmic medication commonly prescribed for neuropathic pain.
It is generally recognized for a favorable side-effect profile, with gastritis being the most frequent adverse event.
Ophthalmic side effects of mexilitine are not widely documented.

Purpose of the Study:

To report two cases suggesting mexilitine may induce persistent ophthalmic changes.
To highlight the potential risks of mexilitine in patients with pre-existing ocular conditions.

Main Methods:

Case report analysis of two patients treated with mexilitine for neuropathic pain.
Clinical examination and follow-up of ophthalmic parameters.

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Main Results:

Both patients experienced persistent ocular changes during mexilitine therapy.
These changes were noted despite the drug's generally low side-effect profile.

Conclusions:

Mexilitine may be associated with persistent ophthalmic alterations.
Caution is advised when prescribing mexilitine to chronic pain patients, particularly those with pre-existing ocular diseases.