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Behaviour profiles in a population of infants later diagnosed as having autistic disorder

Joëlle Malvy1, Catherine Barthélémy, Delphine Damie

  • 1Service Universitaire de Pédopsychiatrie, C. H. U Bretonneau, 2 Boulevard Tonnellé, 37044 Tours Cedex, France. j.malvy@chu-tours.fr

European Child & Adolescent Psychiatry
|April 23, 2004
PubMed

Insights

This study identified four distinct behavioral profiles in infants diagnosed with autism, using the Infant Behavioural Summarised Evaluation (IBSE) scale. These early autism markers reveal heterogeneity and aid in precise clinical subtyping for future research.

Area of Science:

  • Developmental Psychology
  • Neuroscience
  • Pediatrics

Background:

  • Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition.
  • Early identification and understanding of heterogeneity in autism are crucial for effective intervention.
  • Previous research has focused on older children, necessitating studies on early markers.

Purpose of the Study:

  • To identify objective early clinical markers of autism heterogeneity in infants.
  • To describe distinct behavioral profiles in infants later diagnosed with autistic disorder.
  • To contribute to a better understanding of the onset of autistic disorder.

Main Methods:

  • Studied a cohort of 74 infants (6-35 months) diagnosed with autistic disorder.
  • Utilized the Infant Behavioural Summarised Evaluation (IBSE) scale, focusing on 13 selected items.
  • Applied correspondence analysis followed by cluster analysis to identify behavioral profiles.

Main Results:

  • Identified four distinct behavioral profiles in infants with autism.
  • These profiles were differentiated by five key behaviors: activity, auditory perception, sensorimotility, eye contact, and object use.
  • The identified early profiles align with those observed in older children with autism.

Conclusions:

  • This study provides an objective description of early clinical markers for autism heterogeneity.
  • The findings support precise clinical subtyping of early autism.
  • These early identified subtypes are valuable for future bioclinical studies in autism.

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