Aglacins I-K, three highly methoxylated lignans from Aglaia cordata

Further chemical investigation of the stem bark of Aglaia cordata has led to the isolation and identification of three new lignans, namely, aglacins I-K (1-3), all of which contain two contiguous trimethoxylated phenyl systems. Among them, aglacins I and J (1 and 2) are new members of the aryltetralin cyclic lactol class, while aglacin K (3) is a new example of tetrahydrofuran lignan. The structures of these compounds were established on the basis of spectroscopic data interpretation.