Talaroindiones A-C, New Polyketides Characterized From the Cold-Seep-Derived Talaromyces indigoticus CS-469.
Ruo-Xi Deng1,2,3, Xiao-Ming Li1,2,3, Bin-Gui Wang1,2,3
1Laboratory of Experimental Marine Biology, Shandong Province Key Laboratory of Marine Biodiversity and Bio-Resource Sustainable Utilization, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China.
Chemistry & Biodiversity
|May 4, 2026
Summary
Marine fungus Talaromyces indigoticus yielded novel polyketides talaroindiones A-C and known diphenyl ethers. Compound 4 showed potent broad-spectrum antibacterial activity, particularly against Vibrio species.
Area of Science:
- Marine Natural Products Chemistry
- Fungal Secondary Metabolites
- Antimicrobial Discovery
Background:
- Marine-derived fungi are a rich source of structurally diverse secondary metabolites.
- Talaromyces indigoticus is a fungal species known to produce various bioactive compounds.
- Exploring novel compounds from marine fungi can lead to new therapeutic agents.
Purpose of the Study:
- To isolate and characterize novel polyketides from Talaromyces indigoticus.
- To evaluate the antibacterial potential of isolated compounds.
- To identify new leads for antibacterial drug development.
Main Methods:
- Extraction and isolation of fungal metabolites using chromatographic techniques.
- Structure elucidation of novel compounds via comprehensive spectroscopic analysis (NMR, MS) and single-crystal X-ray diffraction.
- Determination of absolute configurations using TDDFT-ECD calculations and comparison of optical rotations.
- Antibacterial activity screening using broth microdilution assays to determine minimum inhibitory concentrations (MIC).
Main Results:
- Three new polyketides, talaroindiones A-C (1-3), were isolated and characterized.
- Two known diphenyl ether derivatives (4 and 5) were also identified.
- Compound 4 demonstrated significant broad-spectrum antibacterial activity against six bacterial strains.
- Compound 4 exhibited potent activity against Vibrio harveyi and Vibrio parahaemolyticus, with MIC values as low as 2 µg/mL.
Conclusions:
- Talaromyces indigoticus CS-469 produces novel polyketides with potential biological activities.
- Compound 4 is a promising candidate for further investigation as an antibacterial agent, especially against Vibrio pathogens.
- This study highlights the value of marine-derived fungi in the search for new antimicrobials.
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