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Published on: May 23, 2025
Iron, atherosclerosis, and neurodegeneration: a key role for cholesterol in promoting iron-dependent oxidative
1Department of Anatomy, National University of Singapore, Singapore 119260. antongwy@nus.edu.sg
Abstract:
This article reviews the roles and interactions of iron, atherosclerosis, and neurodegeneration. It highlights the importance of cholesterol in promoting iron-dependent oxidative damage. An intriguing possibility is that hypercholesterolemia can increase brain iron load and both the aggregation of beta-amyloid and the ability of iron on plaques to catalyze oxidative damage. This could explain why hypercholesterolemia is a risk factor for Alzheimer's disease. Further work is necessary to study the mechanism of increased iron transport across the blood brain barrier in atherosclerosis.
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