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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 15, 2010
KSHV/HHV8-associated lymphoma simulating anaplastic large cell lymphoma
Qin Huang1, Karen L Chang, Karl K Gaal
1Division of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA. qhuang@coh.org
The American Journal of Surgical Pathology
|April 24, 2004
Summary
This study details a rare KSHV/HHV8-associated lymphoma in an HIV-positive patient, presenting unique histological and immunophenotypic features. The findings expand the understanding of KSHV/HHV8-related B-cell lymphomas.
Area of Science:
- Oncology
- Virology
- Immunology
Background:
- Kaposi sarcoma herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is an oncogenic gammaherpesvirus.
- HIV-seropositivity is a significant risk factor for KSHV-associated malignancies, including lymphomas.
- B-cell lymphomas represent a diverse group of lymphoid neoplasms with varying clinical and pathological features.
Observation:
- A unique case of KSHV/HHV8-associated lymphoma was identified in a 49-year-old HIV-seropositive male.
- The lymphoma, located in the cervical lymph nodes, exhibited preferential sinusoidal infiltration and anaplastic cellular morphology.
- Histological and immunophenotypic analysis closely mimicked classic anaplastic large cell lymphoma.
Findings:
- Immunohistochemical staining confirmed strong positivity for KSHV/HHV8 latency-associated nuclear antigen in lymphoma cells.
- PCR analysis verified the presence of KSHV/HHV8 infection.
- Molecular studies revealed a clear B-cell lineage with immunoglobulin gene rearrangements, excluding Epstein-Barr virus association.
Implications:
- This case expands the known spectrum of KSHV/HHV8-associated B-cell lymphomas.
- Understanding such unique presentations is crucial for accurate diagnosis and management of KSHV/HHV8-related lymphoproliferative disorders.
- Further research into KSHV/HHV8 pathogenesis in immunocompromised individuals is warranted.
