Related Experiment Video
Updated: Aug 24, 2026

Enhanced Rabies Surveillance Using a Direct Rapid Immunohistochemical Test
Published on: April 30, 2019
Has surveillance been adequate to detect endemic measles in the United States?
Rafael Harpaz1, Mark J Papania, Mary M McCauley
1Epidemiology and Surveillance Division, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. rzh6@cdc.gov.
Abstract:
Evidence that endemic measles has been eliminated in the United States rests on the performance of the surveillance system. Information from national surveillance data allows us to evaluate the adequacy of national surveillance to detect the circulation of endemic measles. Sources of data include measles report dates, international importation status, and the size of chains of measles transmission. The proportion of chains of measles transmission that can be epidemiologically linked to international importations is high (62%), as would be expected if measles is no longer circulating; the number of imported cases, although lower than estimated expected values, is within a reasonable range of expectation. National surveillance detects even small outbreaks, so larger outbreaks that are the marker for endemic transmission would almost certainly be detected. Few unreported cases of measles are detected when health departments conduct careful investigations in response to reports of an index case. Surveillance appears to be adequate to support the contention that measles is no longer endemic in the United States.
Related Concept Videos
Investigation of Disease Outbreaks
Enzyme-Linked Immunosorbent Assay
There are many different types of ELISAs, but they all involve an antibody molecule whose constant region binds an enzyme, leaving the variable region free to bind its specific antigen. Enzyme-substrate reaction allows the antigen to be visualized or quantified.

