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Related Experiment Videos

Glycerol for acute stroke.

E Righetti1, M G Celani, T Cantisani

  • 1Stroke Service, USL 2, Via Guerra 17, Perugia, Italy, 06127.

The Cochrane Database of Systematic Reviews
|April 24, 2004
PubMed
Summary
This summary is machine-generated.

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Intravenous glycerol may reduce short-term death in ischemic stroke patients but offers no long-term survival benefit. Further research is needed due to wide confidence intervals and pre-CT era trial data.

Area of Science:

  • Neurology
  • Clinical Trials
  • Stroke Management

Background:

  • Brain edema is a critical factor in early mortality following stroke.
  • Glycerol, a hyperosmolar agent, is proposed to mitigate brain edema.

Purpose of the Study:

  • To evaluate the efficacy and safety of intravenous glycerol in acute ischemic and hemorrhagic stroke.
  • To assess glycerol's impact on short-term and long-term mortality and functional outcomes.

Main Methods:

  • Systematic review of 11 completed randomized controlled trials (RCTs) including published and unpublished data.
  • Searched Cochrane Stroke Group trials register (up to January 2003).
  • Data extraction and quality assessment by independent reviewers focusing on mortality, functional outcome, and adverse events.

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Main Results:

  • Glycerol showed a non-significant reduction in short-term mortality across all stroke types (OR 0.78).
  • A significant reduction in short-term mortality was observed in patients with definite or probable ischemic stroke (OR 0.65).
  • No significant difference in long-term mortality (OR 0.98) or functional outcome was found; glycerol-induced hemolysis was noted as an adverse effect.

Conclusions:

  • Intravenous glycerol may improve short-term survival in ischemic stroke, but findings require cautious interpretation due to small sample sizes and pre-CT era data.
  • Lack of evidence for long-term survival benefit does not support routine or selective use of glycerol in acute stroke management.