Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Propranolol for migraine prophylaxis.

K Linde1, K Rossnagel

  • 1Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universität, Kaiserstr. 9, München, Germany, 80801.

The Cochrane Database of Systematic Reviews
|April 24, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multimode objective lens for momentum microscopy and x-ray photoemission electron microscopy: Experiments.

The Review of scientific instruments·2026
Same author

Chirality Switching in 1<i>T</i>-TaS<sub>2</sub> by Highly Charged Ion Irradiation.

Nano letters·2026
Same author

Polaronic Quasiparticles in the Valence-Transition Compound TmSe_{1-x}Te_{x}.

Physical review letters·2025
Same author

Chirality in the Kagome Metal CsV_{3}Sb_{5}.

Physical review letters·2025
Same author

Circular dichroism in hard X-ray photoelectron diffraction observed by time-of-flight momentum microscopy.

Ultramicroscopy·2023
Same author

Predictors and outcomes in primary depression care (POKAL) - a research training group develops an innovative approach to collaborative care.

BMC primary care·2022
Same journal

Interventions to prevent or cease electronic cigarette use in children and adolescents.

The Cochrane database of systematic reviews·2026
Same journal

Drugs to improve anaemia, quality of life, and physical function in people with myelodysplastic syndromes (MDS).

The Cochrane database of systematic reviews·2026
Same journal

Interventions for smoking cessation in inpatient psychiatry settings.

The Cochrane database of systematic reviews·2026
Same journal

Mechanical thromboprophylaxis for preventing intradialytic hypotension in people undergoing maintenance haemodialysis.

The Cochrane database of systematic reviews·2026
Same journal

Prognostic models for predicting intensive care unit admission or mortality in critically ill adults not yet been admitted to the intensive care unit.

The Cochrane database of systematic reviews·2026
Same journal

Views and experiences of weight management for people living with mobility‑limiting conditions, intellectual disabilities or severe mental illness: a qualitative evidence synthesis.

The Cochrane database of systematic reviews·2026
See all related articles

Propranolol effectively reduces migraine frequency compared to placebo in short-term treatment. It appears as effective as other prophylactic migraine drugs, though long-term data is limited.

Area of Science:

  • Neurology
  • Pharmacology
  • Clinical Trials

Background:

  • Propranolol is a widely used medication for migraine prevention.
  • Evidence supporting its efficacy against placebo and other prophylactic agents requires synthesis.

Purpose of the Study:

  • To evaluate the efficacy of propranolol versus placebo for migraine prophylaxis.
  • To assess propranolol's effectiveness compared to other migraine prophylactic drugs.

Main Methods:

  • Systematic review and meta-analysis of randomized and quasi-randomized controlled trials.
  • Searched MEDLINE/PubMed and Cochrane Central Register up to May 2003.
  • Included trials of at least 4 weeks duration in adult migraine sufferers.

Main Results:

Related Experiment Videos

  • 58 trials (5072 participants) met inclusion criteria; 26 compared propranolol to placebo, 47 to other drugs.
  • Majority of trials had methodological shortcomings, including high dropout rates.
  • Propranolol demonstrated clear short-term efficacy over placebo; comparisons with other drugs showed no significant differences.

Conclusions:

  • Strong evidence supports propranolol's short-term effectiveness for migraine prophylaxis compared to placebo.
  • Long-term efficacy data for propranolol is currently lacking.
  • Propranolol appears to be as effective and safe as alternative prophylactic medications for migraine.