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Acute peripheral vertigo: involvement of the hemostatic system
Bruno Fattori1, Andrea Nacci, P L Ghilardi
1Department of Neuroscience, Ear, Nose, and Throat Unit, University of Pisa, Via Savi n. 10, I-56126 Pisa, Italy. bfattori@ent.med.unipi.it
The International Tinnitus Journal
|April 27, 2004
Summary
Patients with acute peripheral vestibulopathy (APV) show significant hemostatic system involvement, including elevated fibrinogen, D-dimer, and lipoprotein (a) levels. These findings suggest vascular and hemostatic factors may contribute to APV beyond viral infections.
Area of Science:
- Neurology
- Hematology
- Otolaryngology
Background:
- Acute peripheral vestibulopathy (APV) is often linked to viral infections.
- Vascular disorders affecting the labyrinth and hemostasis alterations are potential alternative causes of APV.
Purpose of the Study:
- To investigate the role of the hemostatic system in patients diagnosed with unilateral acute peripheral vestibulopathy (APV).
- To compare blood parameters in APV patients versus a control group with Ménière's disease.
Main Methods:
- Blood parameters were analyzed in 45 APV patients and 25 Ménière's disease patients.
- Evaluated parameters included lipids, homocysteine, folate, coagulation factors (fibrinogen, D-dimer, antithrombin III, protein C, protein S), and clotting times.
- Leukocyte count and anticardiolipin antibodies were also assessed.
Main Results:
- APV patients exhibited elevated plasma fibrinogen, D-dimer, and lipoprotein (a) levels during the acute phase.
- Higher leukocyte counts and lower serum folate concentrations were observed in APV patients.
- Follow-up revealed prolonged prothrombin time and decreased leukocyte counts in APV patients, while other markers remained unchanged.
Conclusions:
- The study demonstrates significant involvement of the hemostatic system in acute peripheral vestibulopathy.
- Findings suggest that hemostatic alterations may play a crucial role in the pathophysiology of APV.
- Further research into vascular and hemostatic contributions to APV is warranted.