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Immune status with empyema thoracis
1Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. opmpedia@yahoo.co.uk
Indian Journal of Pediatrics
|April 27, 2004
Summary
Children with empyema thoracis show altered humoral and cell-mediated immunity (CMI). CMI was more significantly impacted than humoral immunity, indicating a complex immune response in this condition.
Area of Science:
- Pediatric Immunology
- Infectious Diseases
Background:
- Empyema thoracis is a serious pediatric condition.
- Understanding the immune status in empyema thoracis is crucial for management.
Purpose of the Study:
- To evaluate humoral and cell-mediated immune status in children with empyema thoracis.
- To compare immune markers between patients and healthy controls.
Main Methods:
- Assessed serum IgG, IgA, IgM, and Complement C3 levels.
- Performed cell-mediated immunity (CMI) tests, including purified protein derivative (PPD) skin tests.
- Measured absolute lymphocyte count (ALC) and serum adenosine deaminase (ADA) activity.
Main Results:
- Significantly elevated serum IgG and IgA levels in empyema thoracis patients.
- Increased frequency of negative PPD skin tests, indicating impaired CMI.
- Decreased ALC and elevated serum ADA activity observed in patients.
Conclusions:
- Both humoral and cell-mediated immunity are affected in pediatric empyema thoracis.
- Cell-mediated immunity shows more pronounced changes compared to humoral immunity.