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Immuno-fluorescence Assay of Leptospiral Surface-exposed Proteins
Published on: July 1, 2011
Reemerging leptospirosis, California
Elissa Meites1, Michele T Jay, Stanley Deresinski
1Stanford University School of Medicine, Stanford, California, USA.
Abstract:
Leptospirosis is a reemerging infectious disease in California. Leptospirosis is the most widespread zoonosis throughout the world, though it is infrequently diagnosed in the continental United States. From 1982 to 2001, most reported California cases occurred in previously healthy young adult white men after recreational exposures to contaminated freshwater. We report five recent cases of human leptospirosis acquired in California, including the first documented common-source outbreak of human leptospirosis acquired in this state, and describe the subsequent environmental investigation. Salient features in the California cases include high fever with uniform renal impairment and mild hepatitis. Because leptospirosis can progress rapidly if untreated, this reemerging infection deserves consideration in febrile patients with a history of recreational freshwater exposure, even in states with a low reported incidence of infection.
Insights
Leptospirosis, a widespread zoonotic disease, is reemerging in California. Recent cases highlight its risk after freshwater exposure, emphasizing prompt diagnosis for febrile patients.
Area of Science:
- Infectious Diseases
- Zoonotic Diseases
- Public Health
Background:
- Leptospirosis is a globally prevalent zoonotic disease, infrequently diagnosed in the continental US.
- Historically, California cases (1982-2001) involved young adult males after recreational freshwater exposure.
- This study investigates recent cases and the first documented common-source outbreak in California.
Observation:
- Five recent human leptospirosis cases acquired in California were identified.
- The first documented common-source outbreak of leptospirosis in California was investigated.
- Clinical features included high fever, uniform renal impairment, and mild hepatitis.
Findings:
- Leptospirosis is a reemerging infectious threat in California.
- Recreational freshwater exposure is a significant risk factor.
- The outbreak was linked to environmental contamination.
Implications:
- Leptospirosis requires consideration in febrile patients with freshwater exposure history.
- Early diagnosis and treatment are crucial due to rapid progression.
- Public health awareness and environmental investigations are vital for control.
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