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Recent progress and current problems in management of invasive fungal infections in patients with neoplastic diseases

T J Walsh1, J W Lee, E Roilides

  • 1National Cancer Institute, Bethesda, Maryland.

Current Opinion in Oncology
|August 1, 1992
PubMed

Insights

Cancer patients are susceptible to invasive fungal infections due to weakened immune systems from treatments like chemotherapy. This review covers 1991

Area of Science:

  • Medical Mycology
  • Oncology
  • Immunocompromised Hosts

Background:

  • Neoplastic diseases impair host defense mechanisms.
  • Pharmacologic immunosuppression (chemotherapy, radiation, corticosteroids) increases infection risk.
  • Cancer patients face high susceptibility to invasive fungal infections.

Purpose of the Study:

  • To review recent advancements in managing invasive fungal infections in cancer patients.
  • To highlight current challenges in invasive mycosis for individuals with neoplastic diseases.
  • Focus on progress and problems in 1991.

Main Methods:

  • Literature review focusing on invasive fungal infections in cancer patients.
  • Analysis of etiologic agents and management strategies.
  • Examination of data from 1991.

Main Results:

  • Candida, Aspergillus, and other opportunistic fungi are primary causes of mycoses.
  • Intensive cancer therapies significantly compromise immune function.
  • Progress in management was noted, but challenges persist.

Conclusions:

  • Invasive fungal infections remain a significant threat to cancer patients.
  • Continued research and improved management strategies are crucial.
  • Addressing immunosuppression is key to reducing mycosis incidence.

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