Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Targeting eNOS for stroke protection.

Matthias Endres1, Ulrich Laufs, James K Liao

  • 1Department of Neurology, Charité Hospital, Humboldt University, Schumanstrasse 20/21, D-10117 Berlin, Germany. matthias.endres@charite.de

Trends in Neurosciences
|April 28, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Induction of adipocyte thermogenic program by Rho-associated coiled-coil containing kinase 2.

iScience·2026
Same author

Recurrent Symptomatic Hemorrhage in Cerebral Cavernous Malformations After Discontinuation of Atorvastatin or Placebo.

Journal of the American Heart Association·2026
Same author

Endothelial Rho kinase controls blood vessel integrity and angiogenesis.

Cardiovascular research·2025
Same author

Safety and efficacy of atorvastatin for rebleeding in cerebral cavernous malformations (AT CASH EPOC): a phase 1/2a, randomised placebo-controlled trial.

The Lancet. Neurology·2025
Same author

ARNT-dependent HIF-2α signaling protects cardiac microvascular barrier integrity and heart function post-myocardial infarction.

Communications biology·2025
Same author

Endothelial Rho kinase controls blood vessel integrity and angiogenesis.

bioRxiv : the preprint server for biology·2024
Same journal

Ventral tegmental area circuits in defensive states: Emerging mechanisms of fear and anxiety.

Trends in neurosciences·2026
Same journal

Brain rhythms of depression: A predictive processing perspective.

Trends in neurosciences·2026
Same journal

Building neuroscience capacity in low- and middle-income countries: Lessons from Ghana.

Trends in neurosciences·2026
Same journal

Emulating the periodic table: A unified list of CNS terms and abbreviations for humans and experimental animals.

Trends in neurosciences·2026
Same journal

From chromatin dynamics to brain disease: Polycomb-Trithorax mechanisms in neurodevelopment.

Trends in neurosciences·2026
Same journal

Striatum regulates the cortex via the basal forebrain cholinergic system: A role for substance P.

Trends in neurosciences·2026
See all related articles

Nitric oxide (NO), produced by endothelial NO synthase (eNOS), enhances cerebral blood flow and offers neuroprotection against brain ischemia. Strategies boosting eNOS activity may prevent stroke and treat brain injury.

Area of Science:

  • Vascular Biology
  • Neuroscience
  • Pharmacology

Background:

  • Endothelial nitric oxide synthase (eNOS) generates nitric oxide (NO), vital for vascular homeostasis.
  • NO exhibits vasodilatory, anti-inflammatory, antithrombotic, and antiproliferative effects.
  • Increased NO production can improve cerebral blood flow, offering neuroprotection during brain ischemia.

Purpose of the Study:

  • To explore therapeutic strategies that augment NO production via eNOS.
  • To investigate the neuroprotective potential of enhanced NO bioavailability in cerebral ischemia.

Main Methods:

  • Review of identified modalities that upregulate eNOS expression and/or activity.
  • Analysis of the impact of these modalities on NO bioavailability and cerebral blood flow.

Related Experiment Videos

Main Results:

  • Identified statins, steroid hormones, nutrients, and physical activity as agents that upregulate eNOS.
  • Demonstrated that these interventions increase NO bioavailability, enhancing cerebral blood flow.
  • Established a link between enhanced NO production and protection from ischemic stroke.

Conclusions:

  • Therapeutic targeting of eNOS can increase NO bioavailability, improving cerebral blood flow.
  • Such strategies hold promise for both stroke prevention and treatment of ischemic brain injury.