Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chemotherapy in the elderly.

Stuart M Lichtman1

  • 1Geriatric Oncology, Don Monti Division of Oncology, North Shore University Hospital, 300 Community Drive, Manhasset, NY 11030, USA.

Seminars in Oncology
|April 28, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond Performance Status: Optimize Cancer Care in Older Adults.

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting·2026
Same author

Geriatric assessment is the future: Retiring Karnofsky and ECOG performance status in modern cancer care.

Journal of geriatric oncology·2026
Same author

My Career in Geriatric Oncology.

JCO oncology practice·2025
Same author

Germline landscape of high grade serous ovarian cancer across age groups: Is age just a number?

Gynecologic oncology·2025
Same author

Characteristics of Patients and Prognostic Factors Across Treatment Lines in Metastatic Colorectal Cancer: An Analysis From the Aide et Recherche en Cancérologie Digestive Database.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2025
Same author

Nivolumab for mismatch-repair-deficient or hypermutated gynecologic cancers: a phase 2 trial with biomarker analyses.

Nature medicine·2024
Same journal

A systematic scoping review of cancer-related anemia treatment: Comparative trial outcomes, current guidelines, and future perspectives.

Seminars in oncology·2026
Same journal

Steroid-induced tumor lysis syndrome in solid tumors: A case report and review of the literature.

Seminars in oncology·2026
Same journal

PSMA PET/CT staging in intermediate-risk prostate cancer: Toward risk-adapted implementation.

Seminars in oncology·2026
Same journal

Angiogenesis and the corresponding antiangiogenic therapy in gastroenteropancreatic neuroendocrine neoplasms.

Seminars in oncology·2026
Same journal

Post-translational regulation of steroidogenesis and its clinical relevance in hormone responsive cancers.

Seminars in oncology·2026
Same journal

Physics-informed machine learning for tumor microenvironment-responsive nanomedicine: Recent updates.

Seminars in oncology·2026
See all related articles

Older adults, the fastest-growing population, face a rising cancer burden. Chemotherapy strategies are improving, with many agents showing a beneficial therapeutic index in this age group.

Area of Science:

  • Gerontology
  • Oncology
  • Pharmacology

Background:

  • The population aged 65 and older is rapidly expanding in the US, projected to exceed 20% within 30 years.
  • This demographic experiences over 50% of all cancer diagnoses, indicating a significant and growing cancer burden.
  • Aging is associated with physiological and functional changes that impact drug efficacy and safety.

Purpose of the Study:

  • To review pharmacokinetic data for chemotherapeutic agents in older patients.
  • To discuss strategies for optimizing chemotherapy use in the elderly population.
  • To highlight considerations for safe and effective chemotherapy administration in older adults.

Main Methods:

  • Presentation of pharmacokinetic data for various chemotherapeutic agents.

Related Experiment Videos

  • Discussion of age-related changes in drug metabolism and interpatient variability.
  • Analysis of factors influencing oral chemotherapy choices, including absorption, compliance, and pharmacodynamics.

    • Main Results:

    • Many chemotherapeutic agents demonstrate a favorable therapeutic index in older patients.
    • Oral chemotherapy is increasingly utilized, requiring careful consideration of specific factors.
    • Pharmacokinetic and pharmacodynamic changes in older adults necessitate individualized treatment approaches.

    Conclusions:

    • Understanding aging-related physiological changes is crucial for tailoring chemotherapy.
    • Dose adjustments for end-organ dysfunction (renal, hepatic) are essential for safe chemotherapy administration.
    • Personalized strategies, considering pharmacokinetic and pharmacodynamic profiles, can improve chemotherapy outcomes in older cancer patients.