Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Colon cancer genetics.

H T Lynch1, P Watson, T C Smyrk

  • 1Department of Preventive Medicine/Public Health, Creighton University School of Medicine, Omaha, Nebraska 68178.

Cancer
|September 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MiR-320e is a novel prognostic biomarker in colorectal cancer.

British journal of cancer·2015
Same author

Van-Gogh-like 2 antagonises the canonical WNT pathway and is methylated in colorectal cancers.

British journal of cancer·2013
Same author

Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications.

Clinical genetics·2009
Same author

In vivo effects of mesalazine or E. coli Nissle 1917 on microsatellite instability in ulcerative colitis.

Alimentary pharmacology & therapeutics·2009
Same author

JC virus infects the enteric glia of patients with chronic idiopathic intestinal pseudo-obstruction.

Gut·2008
Same author

Symmetric division of cancer stem cells--a key mechanism in tumor growth that should be targeted in future therapeutic approaches.

Clinical pharmacology and therapeutics·2007
Same journal

Long-term outcomes of evolving treatment regimens in Ewing sarcoma survivors diagnosed 1970-1999: A report from the Childhood Cancer Survivor Study.

Cancer·2026
Same journal

Large-scale osteosarcoma sequencing reveals age-associated genomic architectures.

Cancer·2026
Same journal

EZH2 inhibitor tazemetostat voluntarily withdrawn from market.

Cancer·2026
Same journal

Nivolumab and chemotherapy combination approved for previously untreated Hodgkin lymphoma.

Cancer·2026
Same journal

Most older patients with advanced cancer prioritize QOL over extending survival: A secondary analysis of the GAP70+ trial found that among adults aged 70 and older with advanced, noncurable cancer, nearly three-quarters prioritized maintaining QOL.

Cancer·2026
Same journal

Real-world safety, prognostic, and design considerations in ketogenic diet trials for pancreatic cancer.

Cancer·2026
See all related articles

Understanding colorectal cancer (CRC) risk is complex. This review clarifies hereditary, familial, and sporadic CRC classifications, aiding targeted surveillance and management strategies for better patient outcomes.

Area of Science:

  • Oncology
  • Genetics
  • Epidemiology

Background:

  • Current classification of colorectal cancer (CRC) into hereditary, familial, and sporadic types is operational, not strictly etiological.
  • These categories rely on family history and phenotypic information, lacking precise causal understanding.
  • Distinguishing hereditary CRC is crucial due to its distinct natural history and implications for management.

Purpose of the Study:

  • To review current understanding and operational definitions of hereditary, familial, and sporadic colorectal cancer.
  • To highlight the clinical importance of identifying hereditary CRC and utilizing family history for screening.
  • To explore pathologic features and biomarkers related to CRC causation, particularly genetic susceptibility.

Main Methods:

Related Experiment Videos

  • Review of research on pathologic features and biomarkers associated with CRC causes.
  • Analysis of genetic epidemiology studies focusing on CRC susceptibility.
  • Examination of operational definitions based on family history and phenotypic data.

    • Main Results:

    • Operational definitions for sporadic, familial, and hereditary CRC exist but do not yield etiologically homogeneous groups.
    • Hereditary CRC is characterized by autosomal-dominant inheritance patterns and specific phenotypic signs.
    • Family history, alongside age, is a key factor in determining CRC screening programs.

    Conclusions:

    • Despite limitations, the operational classification of CRC types has pragmatic utility for surveillance and management.
    • Identifying hereditary CRC syndromes is of paramount clinical importance.
    • Understanding the genetic epidemiology of CRC is essential for developing targeted prevention and management strategies.