Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A computer model of the kidney.

L J Goldstein1, E B Rypins

  • 1Department of Surgery, Irvine Medical Center, University of California.

Computer Methods and Programs in Biomedicine
|April 1, 1992
PubMed
Summary

We created a computer model simulating kidney function, calculating urine output and electrolyte excretion based on key physiological factors. This tool aids in understanding how blood flow and hormones impact normal kidney performance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Canadian Surgery Forum.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

An automated tube-type blood viscometer: validation studies.

Biorheology·2005
Same author

Docetaxel combined with trastuzumab is an active regimen in HER-2 3+ overexpressing and fluorescent in situ hybridization-positive metastatic breast cancer: a multi-institutional phase II trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2004
Same author

Economic analysis of conventional-dose chemotherapy compared with high-dose chemotherapy plus autologous hematopoietic stem-cell transplantation for metastatic breast cancer.

Bone marrow transplantation·2003
Same author

Response time of the Opti-Q continuous cardiac output pulmonary artery catheter in the urgent mode to a step change in cardiac output.

Journal of clinical monitoring and computing·2003
Same author

Operable breast cancer.

Current treatment options in oncology·2002

Area of Science:

  • Physiological modeling
  • Renal system simulation
  • Biomedical engineering

Background:

  • Understanding normal kidney function is crucial for diagnosing and treating renal diseases.
  • Existing models may not fully integrate key regulatory factors like hormones and perfusion pressure.
  • Accurate simulation of renal physiology aids in predicting treatment outcomes.

Purpose of the Study:

  • To develop a novel computer model of human renal function.
  • To integrate perfusion pressure, serum electrolytes, and hormone concentrations into a unified model.
  • To simulate urine output and electrolyte excretion in normal kidneys.

Main Methods:

  • Developed a computer model based on Uttamsingh's analytical equations for renal systems.
  • Implemented the model as an electrical circuit for network analysis.
  • Incorporated variables for perfusion pressure, serum sodium, potassium, antidiuretic hormone, and aldosterone.

Main Results:

  • The model successfully derives urine output, urinary sodium, and potassium excretion.
  • The model allows for the study of renal blood flow and humoral influences.
  • It can be used as a stand-alone unit or integrated with other physiological models.

Conclusions:

  • The developed computer model provides a valuable tool for studying normal renal function.
  • It facilitates research into the effects of hemodynamic and hormonal factors on kidney physiology.
  • This model can be a basis for more complex simulations of renal pathologies.

Related Experiment Videos