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Structural and functional changes in spastic skeletal muscle.

Richard L Lieber1, Suzanne Steinman, Ilona A Barash

  • 1Departments of Orthopaedic Surgery and Bioengineering, University of California and Veterans Administration Medical Centers, 3350 La Jolla Village Drive, San Diego, California 92161, USA. rlieber@ucsd.edu

Muscle & Nerve
|April 30, 2004
PubMed
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This summary is machine-generated.

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Spasticity causes structural changes in skeletal muscle, including increased fiber size variability and altered mechanical properties. These muscle alterations, alongside neural factors, are crucial for understanding and treating spasticity.

Area of Science:

  • Biomedical Engineering
  • Muscle Physiology
  • Neurology

Background:

  • Spasticity, a neurological condition, significantly impacts skeletal muscle function.
  • Neural alterations are widely recognized as primary drivers of spasticity.
  • The structural and functional changes within the muscle tissue itself require further elucidation.

Purpose of the Study:

  • To review and synthesize current knowledge on skeletal muscle structural and functional changes secondary to spasticity.
  • To explore intrinsic mechanical property alterations in spastic muscle.
  • To identify potential therapeutic targets within the muscle and extracellular matrix.

Main Methods:

  • Literature review of published studies on spasticity and skeletal muscle.
  • Analysis of findings from mechanical studies on whole limbs and isolated muscle cells.

Related Experiment Videos

  • Examination of evidence for changes in muscle cells and the extracellular matrix.

    • Main Results:

    • Increased fiber size variability is a common finding in spastic skeletal muscle.
    • No consensus exists on shifts in fiber type distribution due to spasticity.
    • Mechanical studies indicate intrinsic changes in passive muscle properties, beyond neural factors.
    • Alterations within muscle cells and the extracellular matrix contribute to tissue changes.

    Conclusions:

    • Spasticity, while multifactorial and neural in origin, induces significant structural alterations in skeletal muscle.
    • Understanding these muscle and extracellular matrix changes is key to developing new therapies.
    • Further research into muscle-specific adaptations can inform conservative and surgical treatment strategies.