Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

p53: 25 years after its discovery.

Lorne J Hofseth1, S Perwez Hussain, Curtis C Harris

  • 1Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Trends in Pharmacological Sciences
|May 1, 2004
PubMed
Summary

The p53 protein, a crucial tumor suppressor, regulates cellular responses to stress, aiding DNA repair or eliminating damaged cells. Its functions are vital for organism protection but often lost in cancer due to mutations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The urinary-metabolite-based lung cancer index (uLCI): an interpretable machine-learning risk model for early-stage disease.

medRxiv : the preprint server for health sciences·2026
Same author

Panaxynol mitigates chemotherapy-induced intestinal mucositis by improving the colonic microenvironment in murine models.

American journal of physiology. Gastrointestinal and liver physiology·2026
Same author

The senescence-inhibitory p53 isoform Δ133p53α represses the proinflammatory chemokine CXCL10 in progeria model mice and naturally aged mice.

bioRxiv : the preprint server for biology·2026
Same author

Microplastics in Early Onset Carcinogenesis.

Carcinogenesis·2026
Same author

Senescence-inhibitory Δ133p53α counteracts accelerated ageing and mortality.

bioRxiv : the preprint server for biology·2026
Same author

Urinary pesticide profiles and liver disease risk in Thailand: a machine-learning risk-prediction model.

medRxiv : the preprint server for health sciences·2026

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • The p53 protein is a critical tumor suppressor discovered 25 years ago.
  • It plays a central role in cellular stress response pathways.
  • Its functions are essential for maintaining genomic stability and preventing cancer.

Purpose of the Study:

  • To review the first 25 years of research on the p53 protein.
  • To highlight its multifaceted roles in cellular stress responses.
  • To underscore its significance in biomedical research, including toxicology and pharmacology.

Main Methods:

  • Literature review of p53 research over 25 years.
  • Analysis of p53's involvement in various cellular processes.
  • Examination of the consequences of p53 mutations.

Related Experiment Videos

Main Results:

  • p53 mediates diverse cellular outcomes including cell-cycle arrest, DNA repair, senescence, differentiation, and apoptosis.
  • These functions are critical for eliminating damaged cells and protecting the organism.
  • Mutations in the p53 gene lead to loss of these protective functions, contributing to tumorigenesis.

Conclusions:

  • The p53 protein is a pivotal regulator of cellular stress responses with profound implications for cancer prevention.
  • Understanding p53's functions and the impact of its mutations remains a major focus in biomedical research.
  • Continued investigation into p53 is crucial for developing novel therapeutic strategies in oncology, toxicology, and pharmacology.