[Switching off the estrogen effect and approaches to its correction]

Area of Science:

• Endocrinology
• Toxicology
• Genetics

Background:

• Potentially sex steroid-related endocrine disruptors (PSEE) pose risks due to their estrogenic and genotoxic effects.
• Achieving an optimal balance between desired hormonal action and minimized genotoxicity is a significant challenge in managing PSEE.
• Understanding PSEE induction and modification is crucial for developing effective prevention strategies.

Purpose of the Study:

• To summarize experimental methods for inducing PSEE.
• To review agents and strategies for modifying or preventing PSEE.
• To identify interventions that optimize the ratio of estrogenic effects to genotoxicity.

Main Methods:

• Review of experimental data on PSEE induction.
• Analysis of various agents tested for PSEE modification/prevention.
• Categorization of inductors (ethanol, tobacco smoke, irradiation, aging) and modifiers (carnosine, N-acetylcysteine, vitamins E & C, melatonin, swimming, ICI 182780).

Main Results:

• Identified multiple agents capable of inducing PSEE.
• Documented diverse substances and lifestyle factors that can modify PSEE.
• Highlighted the potential of specific agents to reduce genotoxicity while maintaining or enhancing hormonal effects.

Conclusions:

• Experimental induction and modification of PSEE are achievable through various agents and interventions.
• Certain compounds and practices show promise in mitigating the adverse genotoxic effects of PSEE.
• Further research is warranted to fully elucidate the mechanisms and optimize the therapeutic potential of PSEE modulators.