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Updated: Aug 24, 2026

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells
Published on: October 10, 2017
Novel function of PS2V: change in conformation of tau proteins
Atsuko Nishikawa1, Takayuki Manabe, Taiichi Katayama
1Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, Japan.
Abstract:
Neurofibrillary tangles (NFTs) are associated with many neurodegenerative disorders, such as Alzheimer's disease (AD). The major components of NFTs are hyper-phosphorylated tau proteins. The alternatively spliced form of the presenilin-2 (PS2) gene (PS2V) has been observed in sporadic AD brains. However, it is not known whether there is a relationship between tau aggregation/hyper-phosphorylation and PS2V expression. In this manuscript, we make the first report of PS2V alterations in the conformation of the tau protein (unknown form of tau) in the human neuroblastoma cell line.
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