Related Experiment Video
Updated: Aug 24, 2026
Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies
Published on: January 7, 2019
Tumor-level serum testosterone associated with human immunodeficiency virus lipodystrophy syndrome
Michael H Dahan1, Larry N Lyle, Ada Wolfsen
1Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, Missouri 63108-2259, USA. dahanhaim@hotmail.com
Background:
Human immunodeficiency virus (HIV) lipodystrophy syndrome consists of insulin resistance, hyperlipidemia, increased waist-to-hip ratios, and relative hyperandrogenemia, which resembles polycystic ovary syndrome.
Case:
A 30-year-old HIV-positive multipara with lipodystrophy syndrome had an elevated level of serum total testosterone (244 ng/dL) in the tumor range.
Conclusion:
In HIV lipodystrophy syndrome, marked elevations of total serum testosterone in the range reserved for androgen-producing tumors may occur. The elevated testosterone levels are derived from the ovary and are responsive to gonadotropin suppression.
