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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
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Clinical features of children with screening-identified evidence of celiac disease

Edward J Hoffenberg1, Lisa M Emery, Katherine J Barriga

  • 1Department of Pediatrics, Children's Hospital, and the University of Colorado School of Medicine, Denver, Colorado, USA. hoffenberg.edward@tchden.org

Pediatrics
|May 4, 2004
PubMed

Insights

Children screening positive for celiac disease autoantibodies show mild growth issues and more symptoms. Further research is needed to understand the benefits and risks of early celiac disease (CD) identification in at-risk populations.

Area of Science:

  • Pediatric Gastroenterology
  • Immunology
  • Autoimmune Diseases

Background:

  • Screening for celiac disease (CD) autoantibodies is common in at-risk groups.
  • The clinical significance of positive autoantibody tests in children is not fully understood.

Purpose of the Study:

  • To evaluate the growth and clinical features of children who test positive for CD-associated autoantibodies.
  • To assess the impact of positive immunoglobulin A antitissue transglutaminase autoantibodies (TG) on pediatric health outcomes.

Main Methods:

  • A case-control study involving HLA-characterized children followed prospectively since birth.
  • Included clinical evaluation, questionnaires, blood draws, and small bowel biopsies.
  • Measured growth, nutrition, and symptom frequency in TG-positive versus TG-negative children.

Main Results:

  • TG-positive children (n=18) had more symptoms than TG-negative controls (n=100).
  • Lower z scores for weight-for-height and BMI were observed in TG-positive children.
  • Irritability, lethargy, abdominal distention/gas, and difficulty with weight gain were associated with positive TG status.

Conclusions:

  • Children identified through screening with positive TG autoantibodies exhibit subtle growth and nutritional changes.
  • These children report a higher frequency of symptoms compared to their negative-matched controls.
  • Further investigation is required to determine the advantages and disadvantages of identifying CD in at-risk pediatric populations.
Abstract

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