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Bone health in pediatric epilepsy
1Department of Neurology, University of Wisconsin-Madison, 600 Highland Drive-H6-575, Madison, WI 53562, USA. sheth@neurology.wisc.edu
Epilepsy & Behavior : E&B
|May 5, 2004
Summary
Pediatric epilepsy and its treatments can negatively impact bone health during critical growth periods. This review highlights the risks of reduced bone mineral density and fractures in children with epilepsy.
Area of Science:
- Pediatric Neurology
- Bone Metabolism
- Pharmacology
Background:
- Childhood and adolescence are crucial for achieving peak bone mineral density.
- Chronic diseases and medications can impair bone health.
- Epilepsy is a common neurological condition in children and adolescents.
Purpose of the Study:
- To review the existing literature on bone health in pediatric epilepsy.
- To identify factors contributing to adverse bone health outcomes in this population.
Main Methods:
- Literature review of studies examining bone health in pediatric epilepsy.
- Analysis of the impact of seizures, associated conditions (e.g., cerebral palsy), and antiepileptic drugs on bone health.
Main Results:
- Antiepileptic drugs like phenytoin, phenobarbital, carbamazepine, and valproate are associated with adverse effects on bone health.
- Reduced bone mineral density and increased risk of fractures are observed in children with epilepsy.
- Physical activity restrictions due to seizures or comorbidities can further compromise bone health.
Conclusions:
- Pediatric epilepsy poses significant risks to skeletal development and bone health.
- Careful monitoring and management of bone health are essential for children with epilepsy.
- Further research is needed to fully understand and mitigate these risks.