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Monitoring adverse reaction to steroid therapy in children

Anju Seth1, Anu Aggarwal

  • 1Department of Pediatrics, Lady Hardinge Medical College and Kalawati Saran Childrens Hospital, New Delhi 110 001, India. docaseth@bol.net.in

Indian Pediatrics
|May 5, 2004
PubMed

Insights

Long-term corticosteroid therapy poses risks. Regular monitoring for adverse effects like Cushing's syndrome, osteopenia, and infections is crucial for early detection and management in patients.

Area of Science:

  • Endocrinology
  • Pharmacology
  • Internal Medicine

Background:

  • Long-term corticosteroid use is associated with numerous adverse effects.
  • Physicians must be aware of these potential complications for effective patient care.

Purpose of the Study:

  • To outline essential monitoring protocols for patients on long-term corticosteroid therapy.
  • To emphasize early detection, management, and prevention of corticosteroid-induced adverse effects.

Main Methods:

  • Regular clinical assessments including weight, height, and blood pressure.
  • Biochemical monitoring: 2-hour postprandial blood sugar and serum electrolytes.
  • Specialized screenings: Ophthalmic evaluations for glaucoma/cataract, annual bone densitometry for osteopenia.

Main Results:

  • Routine monitoring identifies early signs of Cushing's syndrome.
  • Ophthalmic and bone density screenings detect glaucoma, cataracts, and osteopenia.
  • Vigilance for infections, avascular necrosis, myopathy, and pseudotumor cerebri is vital.

Conclusions:

  • A structured monitoring plan is essential for patients on long-term corticosteroids.
  • Proactive management of adverse effects improves patient outcomes and safety.
  • Comprehensive assessments aid in preventing severe complications associated with corticosteroid therapy.

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