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Updated: Aug 24, 2026
A Workflow to Quantitatively Determine Age-Related Macular Degeneration Lesion-Specific Variations in Fundus Autofluorescence
Published on: May 26, 2023
Autofluorescence as a novel approach to diagnosing macular holes
Antonio Pasquale Ciardella1, Grace C Lee, Kevin Langton
1Department of Ophthalmology, Denver Health Medical Center, University of Colorado, 777 Bannock Street, Mail Code 0156, Denver, CO 80204, USA. Antonio.ciardella@dhha.org
Purpose:
To report the capability of autofluorescence as a novel approach to diagnosing macular holes.
Design:
Observational case report.
Methods:
In an institutional study, autofluorescence photos and optical coherence tomography scans of two patients who had surgery for macular holes were reviewed.
Results:
Macular hole cases had a strong subfoveal autofluorescence signal, which disappeared after surgical closure of the macular hole.
Conclusions:
Autofluorescence is a novel approach to demonstrating a macular hole. This technique can also be used to confirm postoperative outcome after macular hole repair. A lack of autofluorescence corresponds to macular hole closure.
