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Rheumatoid vasculitis: becoming extinct?

R A Watts1, J Mooney, S E Lane

  • 1Department of Rheumatology, Ipswich Hospital NHS Trust, Heath Road, Ipswich IP4 5PD, UK. Richard.watts@ipswichhospital.nhs.uk

Rheumatology (Oxford, England)
|May 6, 2004
PubMed
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Systemic rheumatoid vasculitis (SRV) incidence has significantly decreased since the 1980s. This decline in SRV may be linked to improved rheumatoid arthritis (RA) inflammation control and shifts in smoking behaviors.

Area of Science:

  • Rheumatology
  • Epidemiology
  • Public Health

Background:

  • Systemic rheumatoid vasculitis (SRV) is a rare but serious complication of rheumatoid arthritis (RA).
  • SRV incidence rates reportedly rose in the 1970s and 1980s.
  • Significant changes in RA treatment protocols occurred in the 1990s, focusing on aggressive inflammation management.

Purpose of the Study:

  • To investigate the epidemiological trends of SRV.
  • To analyze SRV incidence over a 15-year period in a defined population.
  • To correlate changes in RA treatment with SRV occurrence.

Main Methods:

  • A prospective registry of systemic vasculitis patients was maintained from 1988 to 2002.
  • Patients with new-onset SRV, meeting established criteria, were identified within a specific geographic area.

Related Experiment Videos

  • Population data was utilized to calculate incidence rates.

    • Main Results:

    • The overall annual incidence of SRV was 7.9 per million population.
    • Incidence peaked between 1992-1994 at 15.2/million and reached a nadir in 1998-2000 at 3.0/million.
    • No significant differences in age or disease duration at SRV onset were observed across different time periods.

    Conclusions:

    • The incidence of SRV has markedly declined since the 1980s.
    • Improved control of rheumatoid arthritis inflammation is a potential contributing factor.
    • Changes in population smoking habits may also influence SRV rates.