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Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
Published on: August 9, 2012
Long-term bladder dysfunction and renal function in boys with posterior urethral valves based on urodynamic findings
Mazen A Ghanem1, Katja P Wolffenbuttel, Ann De Vylder
1Department of Pediatric Urology, Sophia Children's Hospital Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
The Journal of Urology
|May 6, 2004
Summary
Posterior urethral valves can lead to bladder dysfunction, impacting kidney function. Even normal urodynamics don't guarantee against renal deterioration, highlighting the importance of monitoring bladder issues in children.
Area of Science:
- Pediatric Urology
- Nephrology
- Congenital Abnormalities
Background:
- Posterior urethral valves (PUV) are a primary cause of congenital obstructive uropathy and childhood renal failure.
- Understanding the long-term impact of bladder dysfunction post-ablation is crucial for managing renal outcomes.
Purpose of the Study:
- To investigate the influence of bladder dysfunction on renal function impairment in children with posterior urethral valves.
- To identify prognostic factors for renal deterioration after valve ablation.
Main Methods:
- Retrospective review of 116 patients with PUV treated with valve ablation.
- Urodynamic studies, assessment of vesicoureteral reflux (VUR), renal dysplasia, and serum creatinine during a mean 10.3-year follow-up.
Main Results:
- Renal function impairment was present in 35% of patients.
- Poor compliance and detrusor overactivity on urodynamics correlated with renal impairment.
- Bilateral VUR and renal dysplasia were also associated with poorer renal function.
Conclusions:
- Bladder dysfunction, including poor compliance and detrusor overactivity, contributes to renal function impairment in PUV patients.
- Normal urodynamic findings do not exclude the risk of renal deterioration.
- Bilateral VUR emerged as an independent prognostic factor for poor renal prognosis.
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