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Related Experiment Videos

Thyroid function in patients with fibromyalgia syndrome.

G Neeck1, W Riedel

  • 1Department of Rheumatology and Physical Medicine, University of Giessen, Bad Nauheim, Germany.

The Journal of Rheumatology
|July 1, 1992
PubMed
Summary

Women with fibromyalgia syndrome show altered thyroid function, including lower thyroid hormone secretion and higher prolactin levels after thyrotropin-releasing hormone (TRH) stimulation. They also exhibit lower calcium and calcitonin levels.

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Area of Science:

  • Endocrinology
  • Rheumatology
  • Neuroendocrinology

Background:

  • Fibromyalgia syndrome (FS) is a chronic pain disorder with complex pathophysiology.
  • Thyroid dysfunction can present with symptoms overlapping those of FS.
  • Previous research on thyroid function in FS has yielded inconsistent results.

Purpose of the Study:

  • To investigate thyroid and prolactin responses to thyrotropin-releasing hormone (TRH) in female patients with primary fibromyalgia syndrome.
  • To compare serum calcium, calcitonin, and parathyroid hormone levels between FS patients and healthy controls.

Main Methods:

  • Intravenous administration of 400 micrograms of TRH to 13 female patients with primary FS and 10 age-matched healthy controls.
  • Measurement of basal and TRH-stimulated thyrotropin, thyroid hormones, and prolactin levels over a 2-hour period.

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  • Assay of total and free serum calcium, calcitonin, and parathyroid hormone levels.

    • Main Results:

    • Patients with primary FS demonstrated significantly blunted thyrotropin and thyroid hormone secretion in response to TRH.
    • A significantly higher increase in prolactin levels was observed in FS patients post-TRH administration.
    • FS patients exhibited significantly lower total and free serum calcium and calcitonin levels compared to controls.

    Conclusions:

    • Primary fibromyalgia syndrome is associated with an altered hypothalamic-pituitary-thyroid axis, characterized by reduced TSH and thyroid hormone response to TRH.
    • Elevated prolactin secretion and decreased calcium and calcitonin levels may be linked to the pathophysiology of fibromyalgia syndrome.
    • These findings suggest potential endocrine contributions to fibromyalgia symptoms and warrant further investigation.