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Updated: Aug 24, 2026

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
Published on: August 10, 2012
Dopamine and cognitive function
Bernard Pillon1, Virginie Czernecki, Bruno Dubois
1INSERM EMI 007 and Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France. bernard.pillon@psl.ap-hop-paris.fr
Purpose Of Review:
Although the cognitive deficits of idiopathic Parkinson's disease are now relatively well known, their neuropsychological and neurobiological basis are still discussed.
Recent Findings:
As well as recent findings on cognitive changes and their underlying mechanisms, we will review new approaches concerning the effects of levo-dihydroxyphenylalanine, those of deep-brain stimulation and recent developments on personality disorders.
Summary:
Future research directions concern the relative influence of the striatofrontal loops in cognition and personality, and the respective contribution of subcortical and cortical lesions or dysfunctions, both in dementia and in specific cognitive and personality changes.
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