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[Orthotopic heart transplantation: a clinical analysis of 43 patients]
1Department of Cardiac Surgery, Union Hospital, Fujian Medical University, Fuzhou 350001, China
Insights
Orthotopic heart transplantation is an effective treatment for end-stage heart disease. Careful patient selection and immunosuppression are crucial for successful outcomes in heart transplant recipients.
Area of Science:
- Cardiology
- Transplantation Surgery
- Immunology
Background:
- End-stage heart disease necessitates advanced treatment options.
- Orthotopic heart transplantation offers a life-saving intervention for eligible patients.
- Understanding the outcomes and influencing factors is vital for improving patient care.
Purpose of the Study:
- To evaluate the clinical experience and outcomes of orthotopic heart transplantation.
- To identify factors influencing the success of heart transplantation.
- To assess the quality of life for long-term survivors.
Main Methods:
- Retrospective analysis of 43 patients undergoing orthotopic heart transplantation between 1995 and 2003.
- Patients had end-stage heart disease, primarily dilated cardiomyopathy.
- Surgical results and post-operative complications were documented.
Main Results:
- Early mortality was 16.3%, with acute right heart failure being the leading cause.
- Late mortality was attributed to acute rejection, infection, and arrhythmia.
- Long-term survivors reported a good quality of life.
Conclusions:
- Orthotopic heart transplantation is an effective treatment for end-stage heart disease.
- Recipient selection, particularly low pulmonary vascular resistance, is critical.
- Optimized immunosuppression strategies enhance transplant success and patient survival.
Objective:
To explore the experience of orthotopic heart transplantation.
Methods:
Between August 1995 and May 2003, 43 patients with end-stage heart disease, 40 males and 3 females, aged 13 approximately 58, the underlying diseases being of dilated cardiomyopathy (39 cases), hypertrophic cardiomyopathy (3 cases), and coronary cardiopathy (1 case), underwent orthotopic heart transplantation in Union Hospital, Fujian Medical University. The surgical results and relevant influencing factors were studied retrospectively.
Results:
Seven cases died of complication within one month postoperationally, among which 5 died of acute right heart failure, 1 of septicemia, and 1 of acute renal failure, with a mortality of 16.3%. 5 cases died much later, among which 2 died of acute rejection, 2 of infection, and 1 of arrhythmia. The long-term survivors had a rather good quality of life.
Conclusion:
Heart transplantation is an effective treatment for patients with end-stage heart diseases. Appropriate selection of recipients with low pulmonary vascular resistance and proper immunosuppression treatment are key measures of successful heart transplantation.
