Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunological memory in humans.

Shane Crotty1, Rafi Ahmed

  • 1Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA.

Seminars in Immunology
|May 8, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

New insights into progenitor exhausted T cell populations.

Nature reviews. Immunology·2026
Same author

Simultaneous TCR and IL-2 agonism selectively enhances epitope-specific CD8 T-cell responses during chronic viral infection.

Journal of virology·2026
Same author

Neuroprotective Phytochemicals Targeting Amyloid and Tau Pathologies.

Current topics in medicinal chemistry·2026
Same author

Coadministration of rapamycin with a DNA/MVA SIV vaccine improves memory CD8+ T cell response.

JCI insight·2026
Same author

CD8+ T cells and Humoral Immunity Influence the Development of Antibody-Dependent Enhancement: Implications for Vaccine Design.

bioRxiv : the preprint server for biology·2026
Same author

Selective depletion of virus-specific CD8 T cells from the liver after PD-1 therapy with Fc-intact antibody during chronic infection.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Myeloid cells as sources and targets of IL-1 family cytokines in cancer.

Seminars in immunology·2026
Same journal

Interleukin-1-mediated inflammatory memory: Protective training or maladaptive tumor imprinting?

Seminars in immunology·2026
Same journal

Chronic stress at the crossroads: Decoding the HPA-SAM-immune-gut axis in inflammatory bowel disease pathogenesis and therapeutics.

Seminars in immunology·2026
Same journal

Protein tyrosine kinases in dendritic cell-mediated anti-cancer immunity.

Seminars in immunology·2026
Same journal

The immune system in Latin America and the Caribbean: Insights into diseases and diversity from local perspectives.

Seminars in immunology·2026
Same journal

Introduction to the special issue: T<sub>H</sub>9 cells in diseases.

Seminars in immunology·2026
See all related articles

Immune memory, crucial for vaccines, is maintained by B and T cells even without persistent antigen exposure. Recent human studies reveal key insights into the longevity of this adaptive immune response.

Area of Science:

  • Immunology
  • Vaccinology

Background:

  • Adaptive immunity relies on specificity and memory for effective responses.
  • Vaccine efficacy is directly linked to the robustness of immune memory.
  • Understanding immune memory maintenance is critical for vaccine development.

Purpose of the Study:

  • To investigate the mechanisms underlying the maintenance of immune memory.
  • To explore the longevity of B and T cell memory in the absence of antigen.
  • To provide insights into factors determining vaccine efficacy.

Main Methods:

  • Analysis of human studies on adaptive immune responses.
  • Investigation of B and T cell behavior in the absence of antigen.
  • Evaluation of immune memory longevity.

Related Experiment Videos

Main Results:

  • Significant progress has been made in understanding immune memory maintenance.
  • Human studies offer new insights into the long-term persistence of immune memory.
  • Immune memory can be maintained in the absence of continuous antigen stimulation.

Conclusions:

  • Immune memory longevity is a key factor in vaccine efficacy.
  • Further research into immune memory maintenance can improve vaccine design.
  • Adaptive immune responses exhibit remarkable persistence.