Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Comparing and optimizing diagnostic tests: an information-theoretical approach.

E Somoza1, D Mossman

  • 1Psychiatry Service, Department of Veterans Affairs Medical Center, Cincinnati, Ohio 45220.

Medical Decision Making : an International Journal of the Society for Medical Decision Making
|July 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cerebrospinal fluid neuroendocrinology of alcohol misusers.

Addiction biology·2016
Same author

Malpractice and the psychiatrist : a primer for residents.

Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry·2014
Same author

The -149C>T SNP within the DeltaDNMT3B gene, is not associated with early disease onset in hereditary non-polyposis colorectal cancer.

Cancer letters·2008
Same author

Avoiding errors about 'margins of error'.

The British journal of psychiatry : the journal of mental science·2007
Same author

What would it take for electrophysiology to become clinically useful?

CNS spectrums·2007
Same author

Metyrapone and cocaine: a double-blind, placebo-controlled drug interaction study.

Pharmacology, biochemistry, and behavior·2005
Same journal

Flexible Survival Extrapolation with Blended Hazards: Accounting for Treatment Effect Waning in Health Technology Assessment.

Medical decision making : an international journal of the Society for Medical Decision Making·2026
Same journal

A Microsimulation Model for Chronic Kidney Disease Progression in Type 2 Diabetes Patients in the United States: Michigan Model for Diabetes-Chronic Kidney Disease Model.

Medical decision making : an international journal of the Society for Medical Decision Making·2026
Same journal

Cardiovascular Risk Estimation and Statin Adherence: A Historical Cohort Study.

Medical decision making : an international journal of the Society for Medical Decision Making·2026
Same journal

Taste or Scale? Methodological Approach to Health Preferences Comparison across Groups.

Medical decision making : an international journal of the Society for Medical Decision Making·2026
Same journal

Mind the Gap: Impact of New Labels on Public Perceptions and Calculated Risk of Adverse Outcomes after a Melanoma In Situ Diagnosis-A Secondary Analysis of an Online Randomized Experiment.

Medical decision making : an international journal of the Society for Medical Decision Making·2026
Same journal

A Metamodel-Based General-Purpose Autocalibration Tool for Simulation Models.

Medical decision making : an international journal of the Society for Medical Decision Making·2026
See all related articles

This study introduces a combined information theory and Receiver Operating Characteristic (ROC) analysis method to evaluate non-binary diagnostic tests. The approach identifies optimal operating points for comparing test performance, especially when precise cost-benefit analysis is difficult.

Area of Science:

  • Medical Diagnostics
  • Information Theory
  • Biostatistics

Background:

  • Assessing non-binary diagnostic tests requires methods to identify optimal operating points.
  • Comparing multiple diagnostic tests in specific clinical contexts is challenging.

Purpose of the Study:

  • To present a combined information theory and Receiver Operating Characteristic (ROC) analysis for evaluating diagnostic tests.
  • To enable comparison of tests at their optimal cutoffs based on specified disease prevalence and test properties.

Main Methods:

  • Integration of information theory principles with ROC analysis.
  • Identification of optimal operating points for diagnostic tests.
  • Evaluation of test performance considering disease prevalence and inherent test characteristics.

Related Experiment Videos

Main Results:

  • The proposed method allows for the evaluation and comparison of diagnostic tests at their optimum performance levels.
  • It provides a framework for selecting the best test in a given clinical scenario when information gain or uncertainty reduction is the primary objective.

Conclusions:

  • The combined information theory and ROC analysis offers a robust approach for assessing non-binary diagnostic tests.
  • This method is particularly useful when precise benefit-cost analyses are not feasible or when the intrinsic value of information is paramount.