[Pathologic diagnosis and differential diagnosis of pulmonary Langerhans' cell histiocytosis]
Ji Li1, Hong-rui Liu, Li-na Guo
1Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Objective:
Morphologic findings of pulmonary Langerhans' cell histiocytosis were analyzed in order to delineate diagnostic features.
Methods:
H&E staining and immunohistochemical studies were performed on 7 cases of pulmonary Langerhans' cell histiocytosis.
Results:
Infiltration by Langerhan's cells was obvious in all 7 cases. Inflammatory cell infiltrates, interstitial fibrosis and focal necrosis may also be seen. The cells expressed S-100 (7/7), CD68 (3/7), and CD1a (5/5).
Conclusions:
In case there is radiologic suspicion of Langerhans' cell histiocytosis, pulmonary biopsy is strongly advised for a definitive diagnosis. S-100 and CD1a immunostaining is also helpful in this respect.
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