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Establishment and Characterization of UTI and CAUTI in a Mouse Model
Published on: June 23, 2015
[Urinary tract infections in children]
1Service de néphrologie pédiatrique, hôpital Trousseau, 75012 Paris. a.bensman@trs.ap-hop-paris.fr
Abstract:
The diagnosis of urinary tract infections is based on the number of colony-forming units that grow on the culture media. The criteria for the diagnosis depends on the method of collection: clean void and bags > 10(5)/mL; transurethral catheterization > 10(4)/mL. The diagnosis of acute pyelonephritis or cystitis is based on clinical and biological signs: unexplained fever, abdominal pains, signs of neonatal infections, elevated white blood cell count, C-reactive or sedimentation rate. After an urinary tract infection, it is important to look for a lithiasis, an obstructive uropathy, a vesico-ureteral reflux and a bladder dysfunction. The child should have a sonogram and a voiding cystourethrography. In case of cystitis the antimicrobial therapy is given orally. In case of pyelonephritis, most of the time the treatment is initially administered parenterally for 3 days and then completed by a 10-day antimicrobial course orally. In a child over 18 months of age who is not toxic appearing without severe uropathy, the antimicrobial therapy can be initiated orally.
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Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...

