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Periodic alternating gaze deviation in infancy.

R H Legge1, H S Weiss, T R Hedges

  • 1Department of Ophthalmology, New England Medical Center, Tufts University, Boston, MA.

Neurology
|September 1, 1992
PubMed
Summary
This summary is machine-generated.

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Periodic alternating gaze, a rare condition, was observed in two infants with early onset. This eye movement disorder is linked to congenital defects in the hindbrain, specifically the inferior cerebellar vermis.

Area of Science:

  • Neurology
  • Pediatrics
  • Neuroscience

Background:

  • Periodic alternating gaze (PAG) is a rare nystagmus variant.
  • Its etiology and associated pathologies are not well-understood.
  • Early-onset forms are exceptionally uncommon.

Observation:

  • Two cases of congenital periodic alternating gaze are presented.
  • Onset was noted at birth and in infancy.
  • Magnetic Resonance Imaging (MRI) revealed significant congenital defects in the posterior cranial fossa in both infants.

Findings:

  • A key shared finding was the absence of normal structures in the inferior cerebellar vermis region.
  • These hindbrain abnormalities were consistently observed.
  • The findings suggest a strong correlation between cerebellar vermis malformations and early-onset PAG.

Related Experiment Videos

Implications:

  • Periodic alternating gaze may serve as a clinical indicator of underlying hindbrain pathology.
  • Further research into cerebellar vermis development and its role in ocular motor control is warranted.
  • Understanding these associations can aid in earlier diagnosis and management of related neurological conditions.