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Chronic corneal perforations.

J S Saini1, A Sharma, S P Grewal

  • 1Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Ophthalmic Surgery
|June 1, 1992
PubMed
Summary
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This study details the causes and treatments for chronic corneal perforations in North India. Tissue adhesive offers a promising, accessible solution for managing these conditions, especially in resource-limited settings.

Area of Science:

  • Ophthalmology
  • Corneal Diseases
  • Wound Healing

Background:

  • Chronic corneal perforations present a significant clinical challenge.
  • Etiologies vary widely, including infections, degenerative conditions, and trauma.

Purpose of the Study:

  • To investigate the etiological profile of chronic corneal perforations.
  • To evaluate management strategies, including tissue adhesive and penetrating keratoplasty.
  • To assess the efficacy of tissue adhesive in healing corneal perforations.

Main Methods:

  • Retrospective analysis of 104 cases with chronic corneal perforations.
  • Management included various surgical techniques and tissue adhesive application.
  • Evaluation of healing factors and treatment outcomes.

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Main Results:

  • Common causes identified: infective keratitis, degenerative keratolysis, neurotrophic keratitis, chemical burns, dry eyes, collagen vascular diseases, and post-cataract extraction.
  • A two-stage tissue adhesive application with debridement showed significant healing.
  • Penetrating keratoplasty achieved comparable success but has accessibility limitations.

Conclusions:

  • Tissue adhesive is an effective and recommended treatment for small corneal perforations, particularly in developing countries.
  • Early detection and management with tissue adhesive are crucial for favorable outcomes.
  • Tissue adhesive offers a viable alternative to penetrating keratoplasty where donor corneas are scarce.