Related Experiment Video
Updated: Aug 24, 2026
In Vitro Thrombosis Test for Ventricular Assist Devices
Published on: March 21, 2025
Validation of the i-STAT handheld activated clotting time for use with bivalirudin
Jeffrey M Schussler1, Stuart R Lander, Laurie A Wissinger
1Department of Cardiology, Baylor University Medical Center, 621 N. Hall Street, Suite 500, Dallas, TX 75226, USA. JeffreSc@baylorhealth.edu
Bivalirudin is being used more frequently as an anticoagulant in the cardiac catheterization laboratory. Newer devices, used to measure activated clotting time (ACT), have not been thoroughly tested for use with bivalirudin. One such device, the i-STAT ACT, measures the generation of activated thrombin to determine the level of anticoagulation. Our study demonstrated a high level of agreement between the i-STAT ACT and the Hemochron ACT in patients anticoagulated with bivalirudin. In addition, the i-STAT was shown to have an extremely high degree of reproducibility.
Bivalirudin is being used more frequently as an anticoagulant in the cardiac catheterization laboratory. Newer devices, used to measure activated clotting time (ACT), have not been thoroughly tested for use with bivalirudin. One such device, the i-STAT ACT, measures the generation of activated thrombin to determine the level of anticoagulation. Our study demonstrated a high level of agreement between the i-STAT ACT and the Hemochron ACT in patients anticoagulated with bivalirudin. In addition, the i-STAT was shown to have an extremely high degree of reproducibility.
