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Updated: Aug 24, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Abstract:
Although guidelines for androgen replacement therapy for older men have been developed by several groups, the data to support treatment are based on the results of only a small number of clinical trials. It has not been definitively established that the decline in testosterone seen in most aging men results in an androgen deficient state with health-related outcomes that can be improved by androgen therapy.
Insights
Androgen replacement therapy guidelines exist for older men, but limited clinical trials show it
Area of Science:
- Gerontology
- Endocrinology
- Men's Health
Background:
- Aging is associated with declining testosterone levels in men.
- Existing guidelines for androgen replacement therapy (ART) in older men are based on limited clinical trial data.
- The clinical significance of testosterone decline in aging men remains unclear.
Purpose of the Study:
- To evaluate the evidence supporting androgen replacement therapy in older men.
- To determine if testosterone decline in aging men constitutes an androgen deficient state.
- To assess the impact of ART on health-related outcomes in aging men.
Main Methods:
- Review of existing clinical trials on androgen replacement therapy.
- Analysis of data supporting current treatment guidelines.
- Assessment of the link between testosterone decline and health outcomes.
Main Results:
- The evidence base for ART guidelines in older men is derived from a small number of clinical trials.
- A definitive androgen deficient state due to testosterone decline in aging men has not been established.
- Improvements in health-related outcomes with ART have not been definitively proven.
Conclusions:
- Current guidelines for androgen replacement therapy in older men lack robust supporting data.
- Further research is needed to establish the efficacy and necessity of ART for aging men.
- The health benefits of treating testosterone decline in older men require further investigation.
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