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Published on: June 20, 2018
[Allergies in children with metabolic nephropathies]
Insights
Children with allergies often have metabolic disorders affecting the kidneys, and those with kidney disease show increased allergic reactions. This suggests a link requiring integrated treatment approaches.
Area of Science:
- Pediatric Nephrology
- Allergology
- Metabolic Disorders
Context:
- Investigated children with allergic diseases and metabolic nephropathies.
- Examined early and senior age groups, including those with oxalate nephropathy, pyelonephritis, and interstitial nephritis.
Purpose:
- To establish the interrelationship between renal pathology and allergic diseases in children.
- To explore the common pathogenetic components in allergic and renal conditions.
Summary:
- A high incidence of metabolic disorders, including crystalluria and erythrocyturia, was observed in children with respiratory allergies, while leukocyturia was common in skin allergies.
- Children with metabolic nephropathies exhibited a high incidence of allergic reactions.
- A correlation was found between atopy signs and more severe nephropathy types.
Impact:
- Highlights the need for integrated immunologic and nephrologic examinations for affected children.
- Emphasizes considering these interconnected factors in developing effective treatment strategies.
Abstract:
The authors describe the results of the follow-up of children of the early age (n-68) and senior age (n-42) with different allergic diseases and 77 children with metabolic nephropathies (oxalate nephropathy, pyelonephritis associated with metabolic disorders, interstitial nephritis). In both age groups, an interrelationship was established between renal pathology in the form of metabolic nephropathies and allergo-pathology. Children with different allergies manifested the high incidence of metabolic disorders, with crystalluria and erythrocyturia being mostly encountered in respiratory allergies whereas leukocyturia largely occurred in skin allergies. At the same time the high incidence of allergic reactions was revealed in children with metabolic nephropathies. A relationship was established between the signs of atopy with graver varieties of nephropathies. The presence of the common pathogenetic components in the development of allergic and renal pathology requires the inclusion of immunologic and nephrologic methods into the complex of those patients' examination and the consideration of those factors in the treatment policy.
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