The role of volume transmission in an endogenous brain

Brain dynamics depends on synaptic, diffusive, and glial activities. Observations indicate that synaptic and diffusive activities modify each other's morphology, and glial activity modifies both. Synaptic activity modifies glial morphology. Whether diffusion modifies glial morphology has not been reported but it is reasonable to expect that it does. The relationship between these three transmission processes forms a closed-loop hierarchy of causation in brain dynamics, and the operation of that hierarchy may account for some of the seemingly bizarre properties of cognitive function.