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Updated: Aug 24, 2026

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
Published on: June 26, 2018
[Studies on the coumarins in the root of Zanthoxylum dimorphophyllum]
Zhao-Yang Tao1, Wan-Sheng Chen, Wei-Dong Zhang
1College of Pharmacy, Second Military University, Shanghai 200433, China.
Objective:
To study the chemical constituents of the dried roots of Zanthoxylum dimorphophyllumr. spinifolium and to find out the active constituents of the plant.
Method:
Modern chromatography was used to purify chemical constituents, and their structures were identified by various spectral methods.
Result:
Four compounds were isolated and identified as isopimpinellin (I), xanthoxyletin (II), 6-(2', 3'-dihydroxy-3'-methyl-butyl)-7-hydroxy-2H-1-benzopyran-2-one (III), 6-(2'-O-beta-D-glucopyranosyloxy, 3'-dihydroxy-3'-methybutyl)-7-hydroxy-2H-1-benzopyran-2-one (IV).
Conclusion:
All of the above compounds were isolated from the above mentioned plant for the first time.
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